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KMID : 0545119970070050329
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Journal of Microbiology and Biotechnology
1997 Volume.7 No. 5 p.329 ~ p.332
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Enantioselective N-Acetylation of 3-Amino-3-phenylpropionic Acid by Cell-free Extracts of Streptomyces neyagawaensis
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Chung, Myung Chul
Lee, Ho Jae/Lee, Choong Hwan/Chun, Hyo Kon/Kho, Yung Hee
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Abstract
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Cell-free extracts of Streptomyces neyagawaensis SL-387 grown on a chemically defined medium supplemented with DL-3-amino-3-phenylpropionic acid (APP) produced N-acetyl-APP (Ac-APP) in the presence of APP and acetyl coenzyme A. The APP obtained by acid hydrolysis of the Ac-APP was D-configuration: [α]_D+6.5˚(H_2O) at 20℃, optical purity 92% enantiomeric excesses (ee). These results suggest that an N-acetyltransferase exists in the cell-free extract as a novel enzyme with specificity for D-APP.
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